Patient Billing

Medicare Patients

Cologuard is now covered for all Medicare patients as described in the CMS National Coverage Decision released on October 9, 2014.

Original Medicare patients will not have any co-pays or co-insurance for Cologuard. 

Medicare Advantage patients may be subject to laboratory co-pays or co-insurance as determined by their plan. For details, please call the plan provider.

Commercial Patients

Out-of-pocket cost for Cologuard varies depending on the patient's insurance company and specific plan. We encourage patients to call their insurance company directly for the most up-to-date information.

Self-Pay Patients

The list price of Cologuard is $649.


Exact Sciences Laboratories handles the entire billing process and discusses billing and insurance with each patient before completing the order. After the Cologuard test is completed, there may be a remaining balance.

Our billing specialists will seek this payment from your patient's insurance carrier on their behalf. We may file several appeals; processes vary by carrier.

If the patient's insurance carrier does not pay the balance in full after our exhaustive efforts, it will become your patient's responsibility.

If your patient has any questions on billing or the status of their claim, our Customer Support Center is open 24 hours a day, 7 days a week, 1-844-870-8878


We accept personal check, Visa, Mastercard, Discover and American Express. Patients can also pay their bill online by visiting

Payments can be mailed to:
Exact Sciences Laboratories LLC, Patient Pay
27280 Network Place
Chicago, IL 60673-1272

When making a payment patients need to include their payment stub and write their order number on the memo line of their check. The order number can be found near the top of the bill.


We offer payment plans for patients in need of financial assistance, as well as discounts for those patients who qualify based on poverty guidelines from the US Department of Health and Human Services. For more information please call 1-844-870-8870.